These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Sensitivity of rat inferior olivary neurons to 3-acetylpyridine.
    Author: Anderson WA, Flumerfelt BA.
    Journal: Brain Res; 1984 Feb; 314(2):285-91. PubMed ID: 6704754.
    Abstract:
    Climbing fiber deafferentation of the weanling rat was performed initially by means of intraperitoneal administration of 3-acetylpyridine (3-AP, 65 mg/kg). This dosage of 3-AP, which has been used routinely to achieve olivary ablations in the adult rat, is inappropriate for the total destruction of the inferior olivary complex in weanling rats (21-23 days). Examination of the inferior olivary complex at both the light and electron microscopic levels has revealed a consistent sparing of neurons within the nucleus beta, the genu of the principal nucleus and the caudal portion of the medial accessory olive following long-term (120 days) 3-AP treatment. Complete olivary ablations in weanling rats were obtained only after the injection of a higher dose of 3-AP (90 mg/kg). It would appear that immature inferior olivary neurons are less sensitive to the toxic effect of 3-AP but become increasingly susceptible to 3-AP with maturation. If the appropriate dosage of 3-AP is employed, however, it can be used reliably to produce a chemical ablation of the total climbing fiber input to the cerebellar cortex in weanling rats.
    [Abstract] [Full Text] [Related] [New Search]