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Title: Observations on plasma and red cell lipids in hereditary spherocytosis. Author: Sugihara T, Yawata Y. Journal: Clin Chim Acta; 1984 Feb 28; 137(2):227-32. PubMed ID: 6705235. Abstract: Plasma lipids and red cell lipids were determined in hereditary spherocytosis (HS), 15 unsplenectomized and eight splenectomized patients. Plasma lipids (cholesterol: total, free and high density lipoproteins, free fatty acids, and phospholipids) were markedly decreased in HS, especially in the unsplenectomized patients. Concomitantly, red cell membrane lipids (free cholesterol and phospholipids: total, phosphatidyl ethanolamine, sphingomyelin, phosphatidyl choline, and lysophosphatidyl choline) were also diminished. The plasma lipids stay low even after splenectomy although partially restored. Thus, decreased membrane surface, a hallmark of HS, could be partly attributed to the diminished membrane lipids induced by plasma lipid abnormalities in the patients.[Abstract] [Full Text] [Related] [New Search]