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  • Title: Clostridium difficile colitis associated with the use of antineoplastic agents.
    Author: Miller SD, Koornhof HJ.
    Journal: Eur J Clin Microbiol; 1984 Feb; 3(1):10-3. PubMed ID: 6705768.
    Abstract:
    Eight patients are presented in whom treatment with antineoplastic agents, in particular the folic acid antagonist methotrexate, precipitated Clostridium difficile-related diarrhoea and pseudomembranous colitis. The clinical presentation of these patients was identical to that encountered in patients developing antibiotic associated diarrhoea and colitis. Clostridium difficile-related diarrhoea and colitis should be suspected in any patient developing diarrhoea during the course of anti-neoplastic chemotherapy or within three weeks of its cessation. This complication is effectively treated with oral vancomycin.
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