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  • Title: Splenic siderosis and parenteral iron dextran in maintenance haemodialysis patients.
    Author: Murray JA, Slater DN, Parsons MA, Fox M, Smith S, Platts MM.
    Journal: J Clin Pathol; 1984 Jan; 37(1):59-64. PubMed ID: 6707221.
    Abstract:
    The histological features of 40 spleens surgically removed from maintenance haemodialysis patients are reported. Twenty-four of the 40 (60%) showed massive iron loading and a significant direct correlation was found between iron loading and the amount of intravenous iron dextran administered. Since parenteral iron dextran appears to be a major factor in causing iron overload in haemodialysis patients its use as a method of iron replacement in these patients would appear inappropriate.
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