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  • Title: Immunological properties of ampicillin polymers.
    Author: Ahlstedt S, Kristofferson A, Svärd PO, Strannegård O.
    Journal: Int Arch Allergy Appl Immunol; 1977; 53(3):247-53. PubMed ID: 67086.
    Abstract:
    The immunologic effects of ampicillin polymers were studied in mice and rabbits. Polymerized ampicillin--in contrast to monomers--had a suppressive effect on the antibody response to penicilloylated proteins. Unfractionated ampicillin polymer, and high molecular weight fractions were found to have an immunogenic effect in mice, when tested by a haemolytic plaque assay. The immunogenic effect of variously sized polymers did not correspond to their antigenic activity as reflected by passive cutaneous anaphylaxis experiments.
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