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  • Title: Chromatin regions, released by endogenous nucleases, are enriched in immunogenic tissue-specific proteins.
    Author: Ermekova VM, Melkonyan OS, Zotova RN, Nazarova LF, Umansky SR.
    Journal: Mol Biol Rep; 1984 Jan; 9(4):263-7. PubMed ID: 6708953.
    Abstract:
    Localization of immunogenic tissue-specific proteins in chromatin regions, hypersensitive to endogenous nucleases, has been studied using rabbit antibodies against rat thymus chromatin. It is shown that the first 1-2,5% of the chromatin (calculating on DNA), released by Mg2+-, Mn2+- and Ca2+/Mg2+-dependent nuclear endonucleases are drastically enriched in tissue-specific antigenic determinants. The released chromatin fractions are found to contain a heterogeneous set of nonhistone proteins and are deficient in histones. The cleavage of nuclear DNA by endogenous acidic nuclease, independent on bivalent ions, resulted in a significantly less enrichment of the released fractions with immunogenic proteins.
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