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  • Title: Cross-reactive idiotypic reactions between hybridoma proteins with or without anti-peroxidase antibody function.
    Author: Ternynck T, Avrameas S.
    Journal: Ann Immunol (Paris); 1984; 135C(1):149-56. PubMed ID: 6712159.
    Abstract:
    Hybridomas from lymph node cells of a mouse C57BL/6 immunized with peroxidase were prepared. Two hybridoma proteins, one with and one without reactivity towards peroxidase, were selected and used to prepare antiidiotypic antisera in rabbits. The idiotypic cross-reactions between these two hybridoma proteins were studied using these antiidiotypic antisera. The results obtained indicate that at least two main idiotopes are present on the non-peroxidase binding hybridoma protein, only one of which is shared by the peroxidase-binding hybridoma protein.
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