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  • Title: [Effect of phosphodiesterase inhibitors on the membrane potential and respiration of mitochondria].
    Author: Liberman EA, Tsofina LM.
    Journal: Biofizika; 1984; 29(1):158-9. PubMed ID: 6713004.
    Abstract:
    Effect of papaverine, 3-isobutyl-1-methylxanthine and SQ-20009 was studied. It was shown that papaverine (50 microM) had rotenone--like action on isolated rat liver mitochondria decreasing their membrane potential and blocking respiration upon beta-oxybutyrate oxidation. Papaverine did not practically influence the membrane potential and oxygen consumption upon succinate oxidation. SQ-20009 effect was much less than that of papaverine. 3-isobutyl-1-methylxanthine (50-200 microM) was uneffective at all.
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