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  • Title: Calcium reactivity and antagonism in portal veins from spontaneously hypertensive and normotensive rats.
    Author: Harris AL, Swamy VC, Triggle DJ.
    Journal: Can J Physiol Pharmacol; 1984 Jan; 62(1):146-50. PubMed ID: 6713276.
    Abstract:
    Reactivities of portal veins from spontaneously hypertensive rats (SHR) and normotensive controls (Wistar Kyoto, WKY) at 5-7 and 15-17 weeks of age were compared. Systolic blood pressures were not different at 5-7 weeks but those of SHR were significantly elevated (177 +/- 4 mmHg) (1 mmHg = 133.322 Pa) at 15-17 weeks. Spontaneous activity, frequency, and tension were greater in SHR for both age groups. Young SHR were more sensitive to K+ at 5-7 weeks but less sensitive at 15-17 weeks than age-matched WKY rats. Sensitivity to Ca2+ in a K+-depolarizing medium was higher in SHR than in WKY for both age groups. Maximum tension responses to K+ or Ca2+ were greater in SHR. The Ca2+ channel antagonists nifedipine, nitrendipine, and nisoldipine were potent inhibitors of both noradrenaline- and K+-induced responses but did not show differences in inhibitory activity between WKY and SHR.
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