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  • Title: Protective effects of Na salicylate against digoxin- and BaCl2-induced arrhythmias in guinea-pigs.
    Author: Brasch H.
    Journal: Eur J Pharmacol; 1984 Feb 17; 98(2):297-301. PubMed ID: 6714313.
    Abstract:
    In pentobarbital-anaesthetized (60 mg/kg i.p.) guinea-pigs injections of Na salicylate (50 and 100 mg/kg i.v.) had a protective effect against arrhythmias induced by digoxin or BaCl2. A lower (25 mg/kg) and a higher (200 mg/kg) dose exerted no clearcut antiarrhythmic effect. Plasma concentrations of Na salicylate up to 1 mg/ml influenced neither the heart rate nor the ECG parameters. The antiarrhythmic effect of the drug may be explained by an inhibition of cardiac cyclooxygenase.
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