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  • Title: Long-term treatment of arterial hypertension with verapamil.
    Author: Wigler I, Peer G, Soferman G, Blum M, Aviram A.
    Journal: Int J Clin Pharmacol Ther Toxicol; 1984 Mar; 22(3):162-6. PubMed ID: 6715085.
    Abstract:
    Based on the vasodilator properties of calcium antagonists, verapamil was recently introduced into the treatment of arterial hypertension. The present study was undertaken to examine the long-term efficacy of this drug in mild and moderate hypertension. In 82 patients with uncontrolled primary or renal hypertension, verapamil was used either alone or in combination with other drugs. In six cases verapamil was withdrawn because of side effects. In the remaining patients a normal average blood pressure was achieved within 7.8 +/- 1.2 weeks of treatment with doses not exceeding 400 mg/day. This effect was maintained for up to 4 years of treatment, although tolerance seemed to develop in about 10% of the patients. In view of this good response and minimal side effects, it is concluded that verapamil is an effective addition to the antihypertensive arsenal.
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