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  • Title: Effects of L-carnitine on adriamycin-induced cardiomyopathy in rabbit.
    Author: Paterna S, Furitano G, Scaffidi L, Barbarino C, Campisi D, Parisi G, Carreca I.
    Journal: Int J Tissue React; 1984; 6(1):91-5. PubMed ID: 6715123.
    Abstract:
    The authors conducted an investigation in order to ascertain whether or not L-carnitine, by promoting the utilization of FFA for energy and neutralizing FFA toxicity occurring after ischaemia, could prevent or confine adriamycin-induced cardiotoxicity in rabbits. The results show that L-carnitine determines a higher survival rate and reduced onset of cardiomyopathy. Histopathological examination of myocardial tissue under light and electron microscopy revealed a marked decrease in mitochondrial lesions.
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