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  • Title: Crystallization and preliminary X-ray study of a complex between d(ATGCAT) and actinomycin D.
    Author: Takusagawa F, Goldstein BM, Youngster S, Jones RA, Berman HM.
    Journal: J Biol Chem; 1984 Apr 25; 259(8):4714-5. PubMed ID: 6715318.
    Abstract:
    Crystals of a 2:1 complex between the self-complementary DNA hexamer d(ATGCAT) and the antitumor drug actinomycin D have been grown from solutions of polyethylene glycol 400. The crystals are orthorhombic with space group P2(1)2(1)2(1) and a = 95.6, b = 42.7, and c = 40.8 A. A Patterson map calculated from preliminary diffractometer data as well as packing considerations suggest a model in which the actinomycin D is intercalated into a double-stranded DNA hexamer. There are four such complexes in the asymmetric unit.
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