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  • Title: Single base deletion in the vasopressin gene is the cause of diabetes insipidus in Brattleboro rats.
    Author: Schmale H, Richter D.
    Journal: Nature; ; 308(5961):705-9. PubMed ID: 6717565.
    Abstract:
    In rats with hereditary hypothalamic diabetes insipidus (Brattleboro rats) the gene for the vasopressin precursor lacks a single G residue in the protein-coding region. The mutation gives rise to an open reading frame predicting a hormone precursor having a different C-terminus.
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