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  • Title: The influence of oxytocin on the steady-state level and accumulation of serotonin in rat brain regions.
    Author: Schwarzberg H, Kovács GL, Telegdy G.
    Journal: Neuropeptides; 1984 Mar; 4(2):145-56. PubMed ID: 6717760.
    Abstract:
    The effects of graded amounts of centrally injected [intracerebroventricular, i.c.v.] oxytocin [OXT] have been studied on the steady-state level and pargyline-induced accumulation of serotonin [5-HT] in the hypothalamus, mesencephalon and dorsal hippocampus of rats. OXT only weakly affected the steady-state level of 5-HT. The pargyline-induced accumulation, on the other hand, was inhibited by central OXT treatment. Whereas OXT inhibited 5-HT accumulation in a dose-dependent manner in the hypothalamus, only the lowest amount of OXT was effective in the mesencephalon and the dorsal hippocampus. The data raise the possibility that an altered 5-HT metabolism is likely to have functional significance in the endocrine and behavioral effects of OXT.
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