These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.
Pubmed for Handhelds
PUBMED FOR HANDHELDS
Search MEDLINE/PubMed
Title: Biliary excretion of acetaminophen in ureter-ligated rats. Author: Siegers CP, Klaassen CD. Journal: Pharmacology; 1984; 28(3):177-80. PubMed ID: 6718484. Abstract: Over one fourth (28.4%) of a 100 mg/kg intravenous dose of acetaminophen (AA) is excreted into bile of conscious rats within 8 h. The main metabolite in bile was the glucuronide (14.3%), followed by the sulfate (8.2%), the glutathione conjugate (4.7%) and unchanged AA (1.2%). In rats with bilateral ligation of the ureters, the amount of total AA excreted into bile was significantly increased to 37.8% of the dose; this enhanced excretion was a consequence of augmented amounts of glucuronide (20.3%) and sulfate (12.0%) whereas the amount of the glutathione conjugate in bile was slightly diminished (4.2%). During renal failure, increased biliary elimination of AA conjugates, mainly as the sulfate, seems to partially compensate the lack of renal excretion.[Abstract] [Full Text] [Related] [New Search]