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  • Title: Incorporation of 15N from glycine into uric acid in gout: a follow-up study.
    Author: Yü TF, Roboz J.
    Journal: Adv Exp Med Biol; 1984; 165 Pt A():119-21. PubMed ID: 6720363.
    Abstract:
    Over-incorporation of 15N-labeled glycine into uric acid indicates over-production of uric acid by de novo purine biosynthesis. This metabolic aberration, though considered to be inborn (3), may be modified by changing of life style, aging and long-term therapy. In the patient under study, the protracted use of allopurinol seems to have played the most important role. Aging contributed to a certain extent, and changing life style was the least significant factor.
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