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  • Title: Pulmonary hemorrhage and acute renal failure in a patient with mixed connective tissue disease.
    Author: Germain MJ, Davidman M.
    Journal: Am J Kidney Dis; 1984 May; 3(6):420-4. PubMed ID: 6720686.
    Abstract:
    Mixed connective tissue disease (MCTD) is considered to have a benign clinical course. Recently, renal disease has been recognized as a frequent complication (20%). This report describes a patient with MCTD who developed pulmonary hemorrhage and acute renal failure. The renal biopsy, in addition to a long-standing membranous nephropathy, revealed a tubulointerstitial nephritis. Immunofluorescent and electron microscopy showed immune complex deposition along the tubular basement membrane. Life-threatening, immune complex-mediated events can occur in the course of MCTD, manifested as pulmonary hemorrhage and tubulointerstitial nephritis.
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