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  • Title: [Isolation and properties of neurospecific proteins 14-3-2, 14-3-3 and 10-40-4].
    Author: Zaĭko SD, Sokolova NI, Kliushnik TP, Burbaeva GSh.
    Journal: Biokhimiia; 1984 Mar; 49(3):355-60. PubMed ID: 6722213.
    Abstract:
    A procedure for isolation of three neurospecific proteins 14-3-2, 14-3-3 and 10-40-4 from human brain is proposed. This procedure includes successive ammonium sulphate precipitation, ion-exchange chromatography on DEAE-cellulose, gel filtration through Sephadex G-150 and ion-exchange chromatography on DEAE-Sephadex A-50. Specific antisera raised against these antigens were used to prove their neurospecificity and to study their species-specificity. Some physico-chemical properties of the isolated proteins were investigated. The 14-3-2 protein--neurospecific enolase, appeared to be much more stable at high temperatures than the non-neuronal enzyme isoform.
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