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  • Title: Effects of azotemia on results of the boronate-agarose affinity and ion-exchange methods for glycated hemoglobin.
    Author: Scott MG, Hoffmann JW, Meltzer VN, Siegfried BA, Chan KM.
    Journal: Clin Chem; 1984 Jun; 30(6):896-8. PubMed ID: 6723047.
    Abstract:
    We evaluated the effect of azotemia on results for glycated hemoglobin as measured by a boronate-agarose affinity method and an ion-exchange chromatographic procedure with saline preincubation and found a good correlation. However, values for glycated hemoglobin in samples from nondiabetic patients with various degrees of azotemia were consistently higher with the ion-exchange column procedure (mean, 8.5%) than with the boronate affinity method (mean, 6.2%). The latter method may thus be preferred for monitoring glycated hemoglobin in diabetic patients with impaired renal function.
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