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  • Title: Studies in bile salt solutions. Deoxycholate stimulation of human milk lipase.
    Author: O'Connor CJ, Wallace RG.
    Journal: FEBS Lett; 1984 May 21; 170(2):375-7. PubMed ID: 6723969.
    Abstract:
    Stimulation of human milk lipase by deoxycholate and its taurine and glycine conjugates was demonstrated by measuring the esterolysis reaction of 4-nitrophenylacetate. The steroidal surfactants did not bind strongly to the polar substrate but they did bind effectively to a hydrophobic site on the enzyme and these bile salt-enzyme complexes were effective catalysts. These results are compared with those for stimulation of the enzyme by cholate surfactants and it has been demonstrated that the absence of a 7 alpha-OH substituent on the steroid nucleus does not prevent stimulation of either the esterolytic or lipolytic activity of the enzyme.
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