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  • Title: Analysis of the effect of bezafibrate on the oxygen dissociation curve of human hemoglobin.
    Author: Wootton R.
    Journal: FEBS Lett; 1984 Jun 11; 171(2):187-91. PubMed ID: 6723982.
    Abstract:
    Analysis of the effects of a range of concentrations of the antihyperlipoproteinemia drug, bezafibrate, on the oxygen dissociation curve of dilute hemoglobin solutions indicates a 4:1 binding stoichiometry with a site binding constant of 434 mol-1 for deoxyhemoglobin. Analysis of the combined effects of a range of bezafibrate and 2,3-diphosphoglycerate (DPG) concentrations indicates that 2 of the 4 bezafibrate sites are in the vicinity of the DPG binding site, and competitive with DPG binding, and 2 of the sites are remote from the DPG binding site.
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