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  • Title: Copper-zinc and manganese superoxide dismutase activities in cardiac and skeletal muscles during aging in male rats.
    Author: Lammi-Keefe CJ, Swan PB, Hegarty PV.
    Journal: Gerontology; 1984; 30(3):153-8. PubMed ID: 6724309.
    Abstract:
    The activities of total superoxide dismutase (SOD) and the manganese (Mn SOD) and copper-zinc (Cu-Zn SOD) forms were determined in the supernatant fraction of heart, liver and six skeletal muscles from rats during aging. Total SOD activity increased in most muscles between 3 and 23 months of age. There was no change in activity in liver between 3 and 19 months of age. The increase in total activity in heart was due to increased Mn SOD activity, whereas increases in skeletal muscles were due to Cu-Zn SOD or to both Cu-Zn and Mn SOD. The nutritional implications during aging are discussed.
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