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  • Title: In vitro interaction of opioid peptides with phospholipids. Formation and characterization of complexes.
    Author: Cherubini O, De Marco V, Roscetti G, Possenti R, Roda LG.
    Journal: Int J Pept Protein Res; 1984 Apr; 23(4):435-42. PubMed ID: 6724805.
    Abstract:
    Interaction of Leu- and Met-enkephalin with phosphatidylserine has been studied by chromatographic and spectrophotometric techniques. The main results of our investigation may be summarized as follows: i) Both enkephalins bind to phosphatidylserine; ii) no difference between the two enkephalins is noticeable; and iii) with both peptides the binding phenomenon leads to the formation of two complexes with a definite stoichiometry which are sterically much smaller than the original vesicles. On the basis of the submitted data, a tentative model of the newly formed complexes is provided.
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