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  • Title: Properties of Sindbis virus variants from infected Culex tarsalis mosquitoes.
    Author: Theilmann D, Eaton BT, Downe AE.
    Journal: J Gen Virol; 1984 May; 65 ( Pt 5)():945-53. PubMed ID: 6726183.
    Abstract:
    Plaque-purified Sindbis virus was passed three times in Culex tarsalis mosquitoes and progeny viruses were isolated by plaque purification on a cloned line of Aedes albopictus cells. Nine of ten clones examined differed from wild-type (wt) virus with respect to their plaque morphology characteristics in chick embryo fibroblast (CEF) and/or A. albopictus cells. Seven clones were temperature-sensitive and failed to replicate or synthesize viral RNA in CEF cells at 41 degrees C. At 35 degrees C in CEF cells the majority of isolates synthesized less viral RNA than wt virus. In contrast, all cloned isolates synthesized viral RNA more rapidly than wild-type virus in A. albopictus cells.
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