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  • Title: Omeprazole, a long-lasting inhibitor of gastric secretion.
    Author: Larson GM, Sullivan HW.
    Journal: J Surg Res; 1984 May; 36(5):503-7. PubMed ID: 6727328.
    Abstract:
    Omeprazole is a potent inhibitor of gastric acid secretion (GAS). It has a unique mechanism of action within the parietal cell where it inhibits (H+-K+) ATPase in secretory membranes. The inhibitory effect of omeprazole was measured over a 24-hr period in the dog. Seventy-five minutes after start of pentagastrin-stimulated GAS, placebo or omeprazole (0.5-3.0 micrograms/kg) iv was given to six dogs and GAS was collected for another 2 hr. Twenty-four hours later, GAS was again measured. Omeprazole produced a prompt and dose-dependent reduction of GAS, and significant suppression (44%) was still present at 24 hr.
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