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  • Title: Cardiac valve prostheses in children without anticoagulation.
    Author: Pass HI, Sade RM, Crawford FA, Hohn AR.
    Journal: J Thorac Cardiovasc Surg; 1984 Jun; 87(6):832-5. PubMed ID: 6727406.
    Abstract:
    We have used the St. Jude Medical cardiac valve prosthesis without postoperative anticoagulation in 34 children undergoing valve replacement since March, 1979. The 19 boys and 15 girls ranged in age from 9 months to 21 years. The valve replaced was mitral in 12 patients, aortic in 14, pulmonary in three, and both mitral and aortic in two. One patient had implantation of a St. Jude Medical valve in a pulmonary conduit, and a left-sided tricuspid valve was replaced in two children. There were three operative deaths, all in infants with complex disease. One patient died suddenly at home 5 weeks after valve replacement, probably of ventricular arrhythmia. During follow-up of 1 to 50 months, comprising 646 patient months, no thromboembolic complications have been observed. Although use of the St. Jude Medical prosthesis without anticoagulation is still investigational, our preliminary data suggest that the risk of thromboembolism in unanticoagulated children with this valve is not greater than that in anticoagulated adults. The results justify continuing investigation of the St. Jude Medical prosthesis in children without postoperative anticoagulation.
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