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  • Title: Prolidase and prolidase deficiency.
    Author: Myara I, Charpentier C, Lemonnier A.
    Journal: Life Sci; 1984 May 21; 34(21):1985-98. PubMed ID: 6727550.
    Abstract:
    Prolidase deficiency seems to be a rather rare metabolic disorder. However, many new cases can be detected because screening is easy to perform and enzymatic confirmation allows the differentiation from other iminodipeptidurias . Clinical symptoms are briefly reviewed, while biological considerations and prolidase properties are exhaustively described. Methods for investigating urinary iminodipeptides are given with results. Moreover, several collagen modifications observed in this disorder led us to formulate a hypothesis for their mechanism. Genetic considerations and treatment attempts are discussed.
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