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  • Title: Inhibition of gastric emptying by peripheral and central fenfluramine in rats: correlation with anorexia.
    Author: Rowland N, Carlton J.
    Journal: Life Sci; 1984 Jun 18; 34(25):2495-9. PubMed ID: 6727578.
    Abstract:
    Rats treated acutely with i.p. fenfluramine showed a profound inhibition of emptying of a chow meal from the stomach. This inhibition was attenuated by previous chronic treatment with fenfluramine. Tolerance to the gastric slowing occurred with as few as 2-4 prior injections, a time course which closely matches tolerance to the anorectic effects of the drug. Cerebroventricular injections of fenfluramine and norfenfluramine in anorectic doses also inhibited gastric emptying.
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