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  • Title: Arginine-vasopressin binding sites in rat brain: a quantitative autoradiographic study.
    Author: Biegon A, Terlou M, Voorhuis TD, de Kloet ER.
    Journal: Neurosci Lett; 1984 Feb 24; 44(3):229-34. PubMed ID: 6728291.
    Abstract:
    Specific binding sites for arginine-vasopressin (AVP) were detected in rat brain after incubation of tissue sections with [3H]AVP. AVP and two selective AVP antagonists are capable of displacing [3H]AVP with an IC50 in the 10(-8)-10(-7) molar range, while oxytocin and ACTH4-10 were much less effective. The neuroanatomical distribution of [3H]AVP-labeled sites was studied with autoradiography utilizing tritium-sensitive LKB film and computerized densitometry for quantitative analyses of the film images. The highest density of [3H]AVP binding sites was observed in hippocampal regions, the lateral septum, olfactory and amygdaloid nuclei, and the nucleus tractus solitarii (NTS) of the brainstem.
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