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  • Title: Receptor-like activity of a monoclonal anti-idiotypic antibody against an anti-acetylcholine receptor antibody.
    Author: Lefvert AK, Fulpius BW.
    Journal: Scand J Immunol; 1984 May; 19(5):485-9. PubMed ID: 6729408.
    Abstract:
    A monoclonal anti-idiotypic antibody against an anti-acetylcholine receptor antibody from a patient with myasthenia gravis was shown to bind the cholinergic ligand alpha-bungarotoxin. This binding could be inhibited by other cholinergic ligands, both antagonists and agonists. The anti-idiotype was also able to elicit the production of anti-receptor antibodies in mice. Thus, the anti-idiotype had functional properties similar to those of the original antigen, the acetylcholine receptor.
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