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  • Title: Effects of dietary linoleic acid on rat platelet ADP-induced aggregation and binding of 125I-fibrinogen.
    Author: McGregor L, Toor B, McGregor JL, Renaud S, Clemetson KJ.
    Journal: Thromb Res; 1984 Apr 01; 34(1):75-9. PubMed ID: 6729770.
    Abstract:
    Platelets from rats fed a diet high in linoleic acid (6%) bound increased amounts of fibrinogen on stimulation with ADP, compared to those from rats fed diets with low (2%) or no linoleic acid. However, this increased fibrinogen binding was associated with a decrease in platelet aggregation induced by ADP. Changes in the linoleic acid concentration in platelet membranes may cause changes in this relationship.
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