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  • Title: [Gentamycin dosage interval in premature infants].
    Author: Van de Bor M, Berger HM, Ruys JH.
    Journal: Tijdschr Kindergeneeskd; 1984 Apr; 52(2):50-2. PubMed ID: 6729805.
    Abstract:
    The effect of dose interval on gentamicin serum concentrations in preterm babies (less than 35 weeks gestational age) was studied in the first week after birth. When gentamicin (2,5 mg/kg) was given intravenously every 12 hours, 53% of the babies had elevated pre dose serum concentrations (greater than 2,0 microgram/ml). This occurred in 27% of the babies when gentamicin was given every 18 hours (p less than 0.01). We recommend that 2.5 mg/kg/18 hours should be used in preterm babies in the first week after birth, although monitoring of gentamicin serum levels remains essential.
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