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  • Title: [Mutagenic activity of the fungicide captan].
    Author: Pilinskaia MA, Shigaeva MKh, Kasinova GV, Malashenko AM, Vyskubenko IF.
    Journal: Tsitol Genet; 1984; 18(2):123-8. PubMed ID: 6729989.
    Abstract:
    A complex study of mutagenic activity of captan (a fungicide) in a series of standard test-systems has shown that the preparation induces gene mutations in certain Salmonella indicator strains (without metabolic activation), increases the frequency of mitotic crossing-over and gene conversion in yeasts (Saccharomyces), possesses a weak cytogenetic action on bone marrow cells in experimental animals, manifests no cytogenetic effect in the lymphocyte culture of human peripheral blood (including a system of microsomal activation). Genetic activity of captan cannot be a limiting criterion of its harmfulness.
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