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  • Title: Suppression of 3H-acetylcholine release from primary nerve cell cultures by tetanus and botulinum-A toxin.
    Author: Bigalke H, Dimpfel W, Habermann E.
    Journal: Naunyn Schmiedebergs Arch Pharmacol; 1978 Jun; 303(2):133-8. PubMed ID: 673020.
    Abstract:
    Primary nerve cell cultures derived from embryonic rat central nervous system form [3H]ACh from exogenous [3H]Ch, and release it upon potassium depolarization. Pretreatment of the cultures with botulinum-A toxin or tetanus toxin diminishes the cellular accumulation of [3H]ACh. Poisoning the cultures during the period of [3H]Ch uptake fails to lower [H]ACh formation. Dependent on dosage, both toxins suppress the release of [3H]ACh upon potassium depolarization. Heat-denaturated toxins as well as tetanus toxin preincubated with tetanus antitoxin were without effect.
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