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  • Title: [Characteristics of aniline, lead nitrate, carbon tetrachloride and formaldehyde as modifiers of chemical carcinogenesis].
    Author: Litvinov NN, Voronin VM, Kazachkov VI.
    Journal: Vopr Onkol; 1984; 30(4):56-60. PubMed ID: 6730407.
    Abstract:
    The modifying effect of aniline, lead nitrate, carbon tetrachloride and formaldehyde on nitrosodimethylamine-induced blastogenesis was studied in chronic experiments on 750 CBA X C57 / Bl6 female mice. A mixture of carcinogen with aniline or formaldehyde given in drinking water for 39 weeks produced a significantly higher tumor incidence. A similar, though statistically insignificant, effect was registered for a mixture of carcinogen and lead citrate or carbon tetrachloride. It is emphasized that aniline and formaldehyde are capable of modifying effect at levels 10 times maximum allowable concentrations.
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