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  • Title: [Effect of ribavirin on the reproduction of influenza B virus].
    Author: Petrova IG, Vorkunova GK, Pushkarskaia NL.
    Journal: Vopr Virusol; 1984; 29(2):158-62. PubMed ID: 6730434.
    Abstract:
    The influence of ribavirin on influenza B virus reproduction was studied at different experimental levels. Ribavirin was found to reduce significantly the production of hemagglutinin and accumulation of infectious influenza B/Lee/40 virus in MDCK cell culture. Synthesis of virus-specific polypeptides of influenza B/Hong Kong/5/72 virus was markedly reduced in its presence. Ribavirin in a dose of 100 mg/kg inhibited the infectious titre of influenza B/Lee/40 virus considerably and prevented the development of inflammatory reactions in pulmonary tissue of white mice.
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