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  • Title: Unique [3H]tryptamine binding sites in rat brain: distribution and pharmacology.
    Author: Wood PL, Pilapil C, LaFaille F, Nair NP, Glennon RA.
    Journal: Arch Int Pharmacodyn Ther; 1984 Apr; 268(2):194-201. PubMed ID: 6732364.
    Abstract:
    [3H]Tryptamine binding in rat brain is widely distributed with highest densities in the cortex, striatum and hippocampus. This binding is stereospecific and is potently displaced by tryptamine analogues and beta-carbolines. Phenethylamines also possess a weaker activity in displacing [3H]tryptamine. The strict structural requirements for binding to this site substantiate its unique character and suggest that it may represent a tryptamine receptor in the CNS.
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