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  • Title: [Role of lung biopsy in a heart surgery center (a new method for the quantitative assessment of pulmonary hypertension by biopsy of the lung of patients with congenital heart defects)].
    Author: Gorchakova AI, Fal'kovskiĭ GE, Gordonova MI, Krymskiĭ LD.
    Journal: Arkh Patol; 1984; 46(4):12-20. PubMed ID: 6732520.
    Abstract:
    Forty-three lung biopsies taken from 42 patients with various congenital heart malformations with high pulmonary hypertension (aged from 8 months to 34 years) were studied by morphological and morphometric methods. Changes in the pulmonary vessels were evaluated according to Heat-Edwards' classification and morphometric classification of Rabinovitch , et al. The morphometric data give some additional information on the growth and development of peripheral vessels, the degree of hypertrophy of tunica media muscularis, a decrease in the size of arteries. The demonstration of considerable reduction in the number of peripheral arteries by morphometry constitutes a serious prognostic sign of further progression of sclerotic changes in the pulmonary vessels even in the early correction of the heart malformation.
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