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  • Title: Calcium regulation of phospholipase A2 is independent of calmodulin.
    Author: Withnall MT, Brown TJ, Diocee BK.
    Journal: Biochem Biophys Res Commun; 1984 Jun 15; 121(2):507-13. PubMed ID: 6732821.
    Abstract:
    There are conflicting data in the literature as to whether or not the Ca2+ activation of phospholipase A2 is mediated by the calcium binding protein calmodulin. In the present study the membrane-bound phospholipase A2 enzymes in rat and human platelets were shown to be absolutely Ca2+ dependent but were not stimulated by the addition of calmodulin. A partially purified phospholipase A2 from rat platelet membrane, which contained little endogenous calmodulin, also was not stimulated by calmodulin addition. Both isolated and membrane-bound phospholipase A2 were inhibited by the non-specific calmodulin antagonist trifluoperazine but the inhibition was not overcome by adding calmodulin. There was thus no evidence from these studies that phospholipase A2 is calmodulin regulated.
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