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  • Title: [Interaction of 8-aza-16-oxasteroids with rat liver microsomal cytochrome P-450].
    Author: Akhrem AA, Popova EM, Bokut' SB, Lis LG, Lakhvich FA.
    Journal: Biokhimiia; 1984 Apr; 49(4):570-6. PubMed ID: 6733160.
    Abstract:
    The interaction of the 8-aza-16-oxasteroid series (8-AS) with cytochrome P-450 from liver microsomes of intact and phenobarbital-induced rats has been studied. It has been shown that 8-AS are the substrates for the cytochrome P-450-dependent enzyme system, and that their affinity for cytochrome P-450 is determined by the structure of the compounds tested. Using inhibitory analysis, the site in the active center of hemoprotein responsible for 8-AS binding was examined. The possibility of direct participation of the 8-AS ketogroup in their binding with cytochrome P-450 is discussed.
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