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  • Title: Transformation of Fanconi's anemia to acute nonlymphocytic leukemia associated with emergence of monosomy 7.
    Author: Stivrins TJ, Davis RB, Sanger W, Fritz J, Purtilo DT.
    Journal: Blood; 1984 Jul; 64(1):173-6. PubMed ID: 6733270.
    Abstract:
    Two sisters in whom a diagnosis of Fanconi's anemia was made at ages 12 and 18 subsequently developed acute nonlymphocytic leukemia (ANLL). A third sibling had previously died at age 11 of apparent sepsis. Both sisters had cytogenetic studies that showed increased chromosomal breakage and a 46,XX karyotype, but subsequently developed ANLL after, or coincident with, the emergence of monosomy 7. These observations suggest that, in addition to myelodysplastic syndromes and defective neutrophil chemotaxis, monosomy 7 may be associated with the emergence of leukemia in this disorder.
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