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  • Title: Hyperosmotic arabinose solutions open the tight junctions between brain capillary endothelial cells in tissue culture.
    Author: Dorovini-Zis K, Bowman PD, Betz AL, Goldstein GW.
    Journal: Brain Res; 1984 Jun 08; 302(2):383-6. PubMed ID: 6733518.
    Abstract:
    Tight junctions between bovine brain capillary endothelial cells in primary cell culture are impermeable to horseradish peroxidase (HRP) after 5 min of incubation. However, following 1-5 min of exposure to 1.6 M arabinose, HRP penetrates the extracellular space between successive tight junctions. Endothelial cells in control cultures contain a small number of cytoplasmic pits and vesicles containing HRP which do not increase in number after hyperosmotic treatment.
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