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  • Title: Diazepam and midazolam increase light slow-wave sleep (SWS1) and decrease wakefulness in rats.
    Author: Radulovacki M, Sreckovic G, Zak R, Zahrebelski G.
    Journal: Brain Res; 1984 Jun 11; 303(1):194-6. PubMed ID: 6733525.
    Abstract:
    Rats implanted with electrodes for polygraphic recordings were injected with diazepam (5 mg/kg, i.p.) or midazolam (10 mg/kg, i.p.) and recorded for 6 h during the 8 h of darkness of a 16 h light/8 h dark cycle. The results show that administration of diazepam reduced SWS1 latency by 92%, and increased SWS1 and total sleep by 255% and 59%, respectively, in comparison to control. Administration of midazolam increased SWS1 by 158% and total sleep by 57% when compared to control. These findings correlate well with the effects of benzodiazepines on sleep stage 2 in humans and indicate that benzodiazepine hypnotics increase only the behaviorally lighter stage of SWS in rats as well as in human subjects.
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