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  • Title: Effects of drug and chemical pretreatments on biliary excretion of phenylcyclohexene in the rat.
    Author: Law FC, Chakrabarti S.
    Journal: Drug Chem Toxicol; 1984; 7(3):273-82. PubMed ID: 6734467.
    Abstract:
    The biliary excretion of 14C-phenylcyclohexene and its metabolites were studied in rats pretreated with an inducer or inhibitor of mixed-function oxidases or with an agent known to deplete liver glutathione. Pretreatment of rats with 3-methylcholanthrene or phenobarbital enhanced the biliary excretion of 14C-phenylcyclohexene and/or its metabolites. Conversely, pretreatment of rats with SKF-525A or piperonyl butoxide decreased the biliary excretion of 14C-phenylcyclohexene and/or its metabolites. In contrast, pretreatment of rats with diethylmaleate did not alter significantly the rate of biliary excretion of radioactivity.
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