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  • Title: [Effect of prolonged intracarotid infusion of euphylline on the brain blood supply and metabolism of cats with intracerebral hemorrhage].
    Author: Plotnikov MB, Saratikov AS.
    Journal: Farmakol Toksikol; 1984; 47(3):50-5. PubMed ID: 6734808.
    Abstract:
    In cats with intracerebral hemorrhage, prolonged intracarotid infusion of euphylline led to unfavourable changes in brain blood supply and metabolism. An increase in the overall cerebral circulation seen during infusion was replaced by a long-term lowering after its completion. Activation of brain oxygen consumption in the presence of the decreased cerebral circulation led to dysproportion between oxygen supply and consumption enhancing cerebral tissue hypoxia. Euphylline-induced glucose consumption with predominance of glucose anaerobic metabolism over aerobic one was followed by lactate accumulation in the brain. Taking into consideration the data obtained it is necessary to be very cautious as regards the use of intracarotid euphylline infusions in patients with subarachnoidal and intracerebral hemorrhages.
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