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  • Title: Inhibition of the thrombin-platelet reaction by hirudin.
    Author: Hoffmann A, Markwardt F.
    Journal: Haemostasis; 1984; 14(2):164-9. PubMed ID: 6735274.
    Abstract:
    The influence of hirudin on the thrombin-platelet reaction was studied by determination of thrombin-induced serotonin release from blood platelets. The dissociation constant for the thrombin-hirudin complex calculated from data obtained by measuring the platelet reaction (Ki 50 pmol/1) was in accordance with the value obtained by determination of fibrinogen clotting. Prevention of the effect of thrombin on platelets required the addition of hirudin in at least 10-fold molar excess. The release of serotonin could be immediately stopped by hirudin at any time when the special conditions for the reaction of thrombin with the tight-binding inhibitor and the receptors on the platelet surface were taken into account.
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