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  • Title: Systemic prophylaxis with gentamicin-metronidazole in appendicectomy and colorectal surgery: a prospective controlled clinical study.
    Author: Gómez-Alonso A, Lozano F, Pérez A, Almazán A, Abdel-lah A, Cuadrado F.
    Journal: Int Surg; 1984; 69(1):17-20. PubMed ID: 6735625.
    Abstract:
    A prospective, randomized, clinical study was carried out in 188 patients undergoing appendicectomy or colorectal surgery to test the efficacy of prophylactic, parenterally-administered antibiotics in the prevention of infection. The results show the effectiveness of the association gentamicin-metronidazole (9.4% of infections), compared to the control group with no antibiotics (39.1% of infections), X2 = 14.1; P less than 0.001).
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