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  • Title: Efficacy of antifungal agents in the cornea. IV. Amphotericin B methyl ester.
    Author: O'Day DM, Ray WA, Head WS, Robinson RD.
    Journal: Invest Ophthalmol Vis Sci; 1984 Jul; 25(7):851-4. PubMed ID: 6735649.
    Abstract:
    Quantitative mycologic techniques were used to evaluate the efficacy of topical amphotericin B methyl ester in two models of yeast infection in rabbit eyes. Doses of 1%, 0.5%, and 0.15% were used in a model of superficial Candida albicans infection. The 1% dose of drug was highly efficacious, abolishing the disease after 2 days of treatment. With doses of 0.5% and 0.15%, decreasing efficacy was observed. Antifungal activity did not deteriorate when 1% prednisolone acetate was administered concomitantly with the 1% dose. In a model of deep stromal infection, the administration of topical 1% amphotericin B methyl ester was highly efficacious when the corneal epithelium was absent. Even in corneas with intact epithelium, a reduced though still significant effect was noted.
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