These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Laboratory tests for defining bactericidal activity as predictors of antibiotic efficacy in the treatment of endocarditis due to Staphylococcus aureus in rabbits.
    Author: Fass RJ.
    Journal: J Infect Dis; 1984 Jun; 149(6):904-12. PubMed ID: 6736681.
    Abstract:
    The validity of laboratory tests that define bactericidal activity to predict antimicrobial efficacy was studied in rabbits with endocarditis due to Staphylococcus aureus, both nafcillin-nontolerant (NT) and nafcillin-tolerant (T). Infected rabbits were treated with nafcillin, clindamycin, chloramphenicol, or no drug (control) for up to 11 days; dosage was designed so that peak antibiotic serum concentration/minimal inhibitory concentration ratios were approximately 50. During treatment, peak and trough serum concentration/minimal bactericidal concentration ratios and peak and trough titers of serum bactericidal antibacterial activity were determined. The rank order of efficacy, as defined by survival, eradication of bacteremia, and sterilization of cardiac vegetations, was nafcillin = clindamycin greater than chloramphenicol greater than control, both adjusted and unadjusted for the challenge strain of S. aureus. Bactericidal activity (observed only with nafcillin plus S. aureus NT) was associated with lower bacterial counts in vegetations at four days but was otherwise unrelated to therapeutic outcome.
    [Abstract] [Full Text] [Related] [New Search]